What are Cosmosomes?

Next-Generation Biomimetic Topical Delivery Technology

Cosmosomes represents a next-generation topical delivery platform that bridges
biomimetic lipid science with modern formulation technology. By closely mimicking the
skin’s natural lipid structure, Cosmosomes ensures enhanced efficacy, safety, and
consumer experience, making it a powerful and versatile solution for high-performance
cosmetic and dermatological applications.
Cosmosomes is a proprietary lipid–surfactant hybrid topical drug and cosmetic delivery
technology engineered to enhance the performance of topical formulations. The
technology is developed using a synergistic combination of polysorbate, glyceryl
monooleate (GMO), glycerine, and lecithin, all of which are well established for their
skin compatibility and functional performance. This advanced delivery platform is
designed to improve skin penetration, formulation stability, hydration, and controlled
delivery of active ingredients.
Cosmosomes self-assembles into a biomimetic micro- to nano-structured delivery matrix
composed of emulsified lipid domains, GMO-based liquid crystalline phases, and lecithin-derived phospholipid bilayers. This unique structural organization closely
mimics the natural lipid architecture of the skin, particularly the intercellular lipid matrix
of the stratum corneum, resulting in superior skin affinity and enhanced delivery of both
hydrophilic and lipophilic actives.
Upon topical application, Cosmosomes spreads uniformly across the skin surface to form
a non-occlusive, breathable film. Glycerine provides immediate and long-lasting
hydration, improving skin softness and elasticity, while non-ionic polysorbates ensure
formulation stability, smooth texture, and consistent performance.

Applications

Cosmosomes are suitable for a wide range of applications, including advanced cosmeceuticals, dermatological and topical drug formulations, anti-aging products, skin-brightening solutions, vitamin and antioxidant delivery systems, botanical extracts, peptides, and sensitive-skin formulations.

Mechanism of Action

After topical application, Cosmosomes operates through a coordinated, multi-step mechanism to enhance active delivery and skin benefits. Glycerine hydrates and plasticizes the stratum corneum, temporarily enhancing skin permeability without compromising barrier integrity. Simultaneously, lecithin-derived phospholipid bilayers and glyceryl monooleate interact with and partially fuse into the intercellular lipid matrix of the stratum corneum. This interaction creates transient lipid pathways that facilitate efficient transport of encapsulated active ingredients into deeper skin layers. The GMO-based liquid crystalline phase functions as a controlled-release reservoir, enabling gradual and sustained release of actives over time. Polysorbates stabilize the lipid structures and promote uniform distribution of both hydrophilic and lipophilic actives across the skin surface. This integrated mechanism results in enhanced penetration, prolonged residence time, improved bioavailability, and reduced irritation, positioning Cosmosomes as a highly efficient delivery platform for advanced cosmeceutical and dermatological topical
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