What are Liposomes?
- Liposomes are spherical lipid vesicles (usually 50–500 nm in diameter particle size) composed of one or more lipid bilayers, as a result of emulsifying natural or synthetic lipids in an aqueous medium.
- A liposomal version of biomolecules may well mimic the body’s own transport system, enhancing uptake and delivery.
- Liposomal encapsulation of active biomolecules improves the stability and bioavailability and enhances the controlled release within the GI tract.
- Liposomal delivery systems offer a promising solution for the delivery of drugs and other less bioavailable active molecules like vitamins & minerals and other bio active molecule, providing improved bioavailability, targeted delivery, increased circulation time, enhanced solubility, reduced toxicity and better stability.
Conventional Liposomes-Limitations
1
Conventional liposomal products available in the market are mostly in liquid or paste form, which may not have much stability since liposomes will break very easily in liquid formulations.
2
Conventional liposomal forms are susceptible to the hydrolysis of the ester bond in both acidic and alkaline media, limiting physical stability and easily undergoing rapid metabolism.
3
Phospholipids might also undergo aggregation or flocculation and fusion or coalescence, modifying the vesicle size, initiating the drug seepage, or harming the encapsulated biomolecules.
4
Additionally, liposomes can be broken down or oxidized, unsaturated acyl chains can be peroxidized, and the glycerol-fatty acid ester bonds can be hydrolyzed.
Why DELT
Dual Encapsulation Liposomal Technology
